One series that had to be pushed back started on Monday with top seed Bourges wanting to avoid a repeat of their last series where they trailed after the first game and they crushed 16 seed Brno 79-49 to make it unlikely for them to be challenged. The series between Charleville and Cukurova that already had the first game postponed last week was further postponed, leaving one game played on Wednesday. 8 seed Nesibe had brought home a 4 point lead and were hopeful of a repeat performance, but 9 seed Olympiacos dominated early and held their early lead for the rest of the game to win 87-68 and advance 166-151 on aggregate. Another game had to be postponed on Thursday, but three more series finished. 10 seed Polkowice had won narrowly at home and were expecting a fight in Orenburg, but Artemis Spanou helped them keep building their margin and winning this game too 87-68 over 7 seed Nadezhda for a final margin of 162-140. Top seed Bourges was not expected to have any trouble after a big first win and it went as expected at home with Iliana Rupert being especially impressive in a 94-55 win to get them past 16 seed Brno 173-104 overall. 2 seed Valencia faced a deficit at home, but overturned it in the first quarter, built a solid lead by halftime and then coasted in the second half for an 86-73 win over Teaira McCowan, Goksen Fitik, and 15 seed Orman to win the aggregate 152-141.
January 17, 2022
(16) Brno vs. (1) Bourges 49-79 ZAB Zaplatova 12 Holmes 10 TBB Yacoubou 16/7r Duchet 16 Rupert 15/15r Miyem 8 Hampton 4 Mann 2
January 19, 2022
(8) Nesibe vs. (9) Olympiacos 68-87 NESI Thomas 17/7a Snytsina 13 Nacickaite 13 Eldas 10 Coates 9/15r OLY Plouffe 14 Stamati 13 Vitola 13 Tolefree 13 Stamolamprou 10 Hamblin 6
Olympiacos advances 166-151
January 20, 2022
(7) Nadezhda vs. (10) Polkowice 68-87 NAD Elonu 15 Medvedeva 15 Hiedeman 12 Gatling 0 POLK Spanou 21/12r Gajda 16/6a Cado 14 Telenga 11 Wheeler 10/9r/8a Mavunga 5/8r
Polkowice advances 162-140
(1) Bourges vs. (16) Brno 94-55 TBB Rupert 27/13r Guapo 13/6r Mann 11 Duchet 10/8a Yacoubou 6/8r Miyem 6 Hampton 3 ZAB Holmes 16 Galickova 15
Bouges advances 173-104
(2) Valencia vs. (15) Orman 86-73 VAL Ouvina 17/7a Gulich 14 Trahan-Davis 13/6r Casas 12 Allen 11 Salvadores 5 ORMAN McCowan 20/15r Fitik 20/6r Lucet 14 Robinson 9
Valencia advances 152-141