The round started on Friday with Ruth Sherrill leading Targu Mures past Targu Secuiesc 89-54. One game could not be played on Saturday, but the day started with Sparkle Taylor and Stephanie Kostowicz leading Satu Mare past Alexandria, which did get a promising debut from Myriam Lara, 79-57. Cluj edged Latinka Dusanic and Brasov 56-55 and Targoviste beat Agronomia 58-47. Brianna Fraser and Sepsi sent a clear message that they should still be considered the favorites after handing Arad their first loss 76-44.
December 10, 2021
Sirius Targu Mures vs. KSE Targu Secuiesc 89-54 TAM Sherrill 22/14r Allen 11 Solyom 10/7r Griffin 8/8r TAS Welch-Coleman 14/6r/6a Corda 13 Debreczi 10/6r Lewis 2 Taylor 1
December 11, 2021
Alexandria vs. Satu Mare 57-79 ALE Lara 20 Benally 13 Pana 10 SAT Taylor 24/9r Kostowicz 20/10r Moore 8 Vuckovic 6
Olimpia Brasov vs. Universitatea Cluj-Napoca 55-56 BRA Dusanic 22/6r Delgado 18/15r CLU Nicholas 19/7r Rubin 14/8r
Targoviste vs. Agronomia Bucuresti 58-47 TAR Stoenescu 18/7r Popescu 17 AGR Sipos 16/14r
Sepsi Sfantu Gheorghe vs. Arad 76-44 SEP Fraser 20/10r Pasic 17/9r Podar 13 Wallace 11 Ghizila 11 ARA Hadzovic 12 Ghita 10/8r Keys 8/6r Akathiotou 6 Vitulova 4/7r