The cup continued with the EuroLeague teams entering in the next round. Lyon won 79-58 over Charleville as most of the games were on Saturday. Landerneau won 57-48 at Charnay. Janee Thompson led Hainaut past Kaleena Mosqueda-Lewis and Roche 80-67. La Glacerie was the last second division team and they could not keep up with Villeneuve, losing 77-39. The last game was played on Sunday and Julie Wojta led Tarbes past Angers 64-55.
Teams with an * are from the second division.
December 4, 2021
Lyon vs. Charleville 79-58 LYO Burdick 17/10r Chartereau 15 Johannes 15 Badiane 10/6r Jocyte 5 Allemand 0 CHM Berkani 17/6r Coffey 10 Fiebich 7 Akhator 7 Gajic 6 Ajemba 5
Charnay vs. Landerneau 48-57 CHA Brown 14 Guennoc 14 Robinson 6 Muzet 5 BRE Macquet 17 Amukamara 12 Muldrow 10/9r Mosengo-Masa 10
Hainaut vs. Roche 80-67 HAI Thompson 20 Lithard 14 Gustavsson 13/8r Williams 13/7r Okou-Zouzouo 10 RVB Mosqueda-Lewis 20 Bankole 11/8r Suarez 10 Kone 10 Clarke 8
La Glacerie* vs. Villeneuve 39-77 GLA Enjolvy 11 Mat. Diop 2 VIL Djaldi-Tabdi 15 Heriaud 13 Diallo 11 Salaun 10/6r Anderson 10 Harmon 2
December 5, 2021
Angers vs. Tarbes 55-64 ANG Slonjsak 15/6r Chidom 14 Peterson 7 Cornelie-Sigmundova 3/7r TAR Wojta 24 Tadic 17/9r Samson 12/6r