The round started with one game on Saturday that saw Myisha Hines-Allen lead Bologna past Faenza 77-43. Robyn Parks and Campobasso had another surprise on their minds in the first game on Sunday, but Ragusa recovered for a 70-64 win. Young Matilde Villa was strong for Costa Masnaga again, but Agnieszka Kaczmarczyk and Lucca won 71-65. Sesto San Giovanni beat Moncalieri 61-40. Shae Kelley and San Martino kept it close against Sandrine Gruda and Schio, but fell 67-60. Venezia rolled past Sassari 85-47. Broni ended the round with a 73-53 win over Empoli.
November 27, 2021
Faenza vs. Bologna 43-77 FAE Policari 12 Kunaiyi-Akpanah 7/12r Davis 7 BOL Hines-Allen 21/7r/7a Dojkic 16 Zandalasini 9/7r Turner 8/10r
November 28, 2021
Ragusa vs. Campobasso 70-64 RAG Kuier 19 Santucci 17/7a Taylor 15/8r Ostarello 3/6r Romeo 2 CAM Parks 21 Chagas 18 Gray 12/8r
Lucca vs. Costa Masnaga 71-65 LUC Kaczmarczyk 23/14r Dietrick 19/8r/8a Wiese 11/6r Gianolla 2 COS M. Villa 24/9r Spreafico 18 Jablonowski 11/16r Jackson 2 Vaughn 0
Moncalieri vs. Sesto San Giovanni 40-61 MON Paixao 12 Williams 6 SES Graves 19/7r Gwathmey 17/8r Raca 8
Schio vs. San Martino di Lupari 67-60 SCH Gruda 25/12r Laksa 12 Collier 5 SAM Kelley 24/11r Mitchell 9/7r
Venezia vs. Sassari 85-47 VEN Bestagno 18/9r Petronyte 15/12r Madera 12/9r Smorto 12 Thornton 10 Anderson 7/6a Attura 5 Penna 2/6a SAS Lucas 14
Broni vs. Empoli 73-53 BRO Galbiati 18 Krivacevic 13/10r Masic 13/6r Dedic 11/8r EMP Bocchetti 14 Ravelli 6 Jeune 5 Williams 3/7r