The season started with champions Fenerbahce hosting Cankaya University and Alina Iagupova led them to an 89-57 win. The two newly promoted teams squared off to start their seasons and it was Jazmine Jones and Antalya getting the early edge 76-75 over Claudia Cuic and Bursa with a late rally. Anete Steinberg and Galatasaray ended the day with a 71-65 win at Botas. Sunday started with Aaryn Ellenberg-Wiley and Hatay using a ridiculous start to breeze past Elazig 103-61. Selale Kepenc made her professional debut for Besiktas in a 74-58 loss to Nesibe. Cukurova will have decisions to make when they have a full roster, but their current group opened league play with an 85-75 win over Kayseri. Orman ended the day with a 94-57 win over Izmit.
October 16, 2021
Fenerbahce vs. Cankaya Universitesi 89-57 FEN Iagupova 29 McBride 15/7r Williams 14/6r Cakir 12/6s Onar 10 Canitez 4/7r Zahui B 0/6r CAU White 18/6r Prince 15 Kizer 10 Babkina 6
Bursa vs. Antalya 75-76 BUR Cuic 23 Doyle 12 Macaualay 10/6r ANT Jones 25/8r Ivankovic 14/11r Davis 13/10r Ozelci 2
Botas vs. Galatasaray 65-71 BOT Dubljevic 19/8r Davis 12 Jurjane 7/10r GAL Steinberga 22/7r Aydin 16 Krajisnik 10/13r Bilgic 10/8a Dungee 2
October 17, 2021
Elazig vs. Hatay 61-103 ELA Morgan 17 Razheva 11 Pulliam 11 Yalcinkaya 6/9r HAT Ellenberg-Wiley 20 Caglar 19/7r Brown 15/9r Gorini 15
Besiktas vs. Nesibe 58-74 BES Jakobsone 17 Yavas 11/6a Guner 11 Hersler 5 Kepenc 0 NES Coates 16/11r Nacickaite 13 Snytsina 10/9r Eldas 10 Thomas 9/6a
Kayseri vs. Cukurova 75-85 KAY Sventoraite 19 Williams 18 Yaya 13/7r/6a CUK Hayes 19 Akalan 15 Hollingsworth 11/6r Yalcin 11 Turner 8 Anigwe 7/10r Zellous 2
Orman vs. Izmit 94-57 ORM McCowan 15/11r Uzun 15 Lucet 14 Robinson 13 Gezgin 12 Fitik 12/7a IZM Marginean 16 Higgins 10/13r Turk 4