The league started with an opening weekend at a single site in Targu Mures for a charity project. There was no generosity towards league newcomers Botosani from Sepsi, which rolled to a 124-47 win on Saturday. Makeda Nicholas lifted Cluj-Napoca past Sara Hinriksdottir and Constanta. Gabriela Irimia had a good game for Targoviste, but Ruth Sherrill and the hosts won 77-47. On Sunday, Sparkle Taylor and Satu Mare started their season with a 91-57 win over Agronomia. Alexandria finally started their season later than expected as Alexis Pana and Analyss Benally made their professional debuts in a 101-58 win over Florina Stanici, Sonia Cazacu, and Rapid. Andreona Keys and Arad finished the day with a 96-45 win over Brasov.
October 2, 2021
Sepsi Sfantu Gheorghe vs. Triumf Botosoani 124-47 SEP Fraser 18/10r Wallace 17 Ghizila 14 Bas 13/9r Orban 12/7r Croitoru 11 Pasic 10/8s BOT Bucuresteanu 15 Karasevich 12 Afanasieva 11/6a
Phoenix Constanta vs. Universitatea Cluj-Napoca 57-66 CON Hinriksdottir 20/8r Vega 14/9r Voica-Nagy 10 CLU Nicholas 30/8r Rubin 16/10r
Targoviste vs. Sirius Targu Mures 47-77 TAR Irimia 21/10r TAM Sherrill 21/9r Griffin 16/17r Solyom 12 Allen 4
October 3, 2021
Agronomia Bucuresti vs. Satu Mare 57-91 AGR Plavitu 15 Sipos 14/7r SAT Taylor 24/11r Moore 15 Vuckovic 11/9r Fodor 11 Ardelean 10 Kostowicz 8/7r
Alexandria vs. Rapid Bucuresti 101-58 ALE Pana 21/10r/9a Burcica 18 Petrova 17/11r Benally 17 Voicu 10/8r RAP Stanici 23 Cazacu 20/7r
Arad vs. Olimpia Brasov 96-45 ARA Keys 20/6r Vitulova 18 Akathiotou 16 Ghita 15 BRA Armanu 19 Delgado 14 Hawkins 0