The season started with the first round at a single site in Moncalieri. Defending champions Venezia played first on Friday won 70-61 over Broni. Shae Kelly and San Martino di Lupari gave Elisabetta Tassinari and Bologna a fight before falling 73-72. On Saturday, Mikayla Vaughn had a strong professional debut and Costa Masnaga had balance in an 83-56 win over Maggie Lucas and Sassari. Campobasso beat Empoli 68-49. Ivana Raca made her professional debut for Sesto San Giovanni, but Asia Taylor and Ragusa rolled to a 75-43 win in the first game on Sunday. Schio is still waiting to field their full roster, but had no trouble in a 68-46 win over Lucca. The two newly promoted teams ended the weekend and Moncalieri had help from their home fans in a 58-52 win over Faenza.
October 1, 2021
Venezia vs. Broni 70-61 VEN M. Bestagno 17 Petronyte 16/12r Anderson 12 Attura 7 Penna 7 BRO Krivacevic 18/11r Dedic 15 E. Bestagno 11
Bologna vs. San Martino di Lupari 73-72 BOL Tassinari 21 Barberis 13/7r Dojkic 12/7r Laterza 11/8r SAM Kelley 21/12r Milazzo 18 Filippi 12 Russo 10 Mitchell 6
October 2, 2021
Sassari vs. Costa Masnaga 56-83 SAS Lucas 26/8r Orazzo 14 MAS Vaughn 19/13r E. Villa 14 Toffali 12 M. Villa 11/6r Jackson 11 Allievi 11 Jablonowski 1
Campobasso vs. Empoli 68-49 CAMP Parks 16 Premasunac 14/11r Nicolodi 14 Trimboli 11 Chagas 1 EMP Bocchetti 17 Williams 16/15r Ravelli 2
October 3, 2021
Ragusa vs. Sesto San Giovanni 75-43 RAG Taylor 22/7r Ruzickova 12/7r Romeo 12 Santucci 7 Ostarello 5/8r SES Crudo 18 Graves 9/8r Gwathmey 4
Schio vs. Lucca 68-46 SCH Laksa 15 Verona 13 Andre’ 11/14r Sottana 10 LUC Dietrick 15 Miccoli 10
Moncalieri vs. Faenza 58-52 MON Miletic 15/11r Paixao 12 Williams 11/9r Katshitshi 10 FAE Kunaiyi-Akpanah 11/16r Policari 11 Davis 10/7r